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Prohibited substance

Procainamide (INN), its salts and derivatives

CAS 51-06-9
5

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Procainamide is a prescription class I antiarrhythmic drug listed as prohibited in cosmetics under EU Annex II. It carries serious cardiac and lupus-like systemic risks and has no role in skincare products.

Skin benefits

  • No cosmetic benefit
  • Pharmaceutical antiarrhythmic only
  • Listed solely to identify and exclude from formulations

Known concerns

  • Prescription class I antiarrhythmic drug
  • Risk of lupus-like syndrome and serious cardiac effects
  • Banned in cosmetics under EU Annex II prohibited substances
  • No safe topical cosmetic use established

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Related prohibited substances

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.