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Prohibited substance

Neostigmine Methylsulfate

CAS 51-60-5
5

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Neostigmine Methylsulfate is a pharmaceutical acetylcholinesterase inhibitor prohibited in cosmetics under EU Annex II. It is a serious systemic drug with neuromuscular effects and no legitimate skincare use.

Skin benefits

  • No cosmetic benefit
  • Pharmaceutical anticholinesterase only
  • Listed for regulatory transparency

Known concerns

  • Reversible acetylcholinesterase inhibitor used as a parenteral drug
  • Banned in cosmetics under EU Annex II prohibited substances
  • Serious cardiovascular and neuromuscular side effects
  • No safe topical cosmetic application established

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.