Skin Conditioning
PALMITOYL OLIGOPEPTIDE-226
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
A palmitic-acid-conjugated oligopeptide for skin conditioning. Lipidation improves skin penetration; independent safety data is limited.
Palmitoyl Oligopeptide-226 is an oligopeptide N-terminally conjugated to a palmitic acid (C16) chain, formulated for cosmetic skin-conditioning use. The palmitoyl moiety improves stratum corneum penetration relative to unmodified peptides — a strategy popularized by Matrixyl-type peptides — at parts-per-million use levels. No independent CIR or SCCS review of this specific INCI is available; efficacy claims rely on supplier studies. The class as a whole has a long market history and a generally low-irritation profile. Listed in EU CosIng. Conservative tier: yellow with low evidence.
Function
Skin benefits
- Lipidation improves skin uptake
- Trace-level skin conditioning
- Compatible with most leave-on formulas
Known concerns
- Limited independent safety data
- No CIR/SCCS monograph
- Slightly higher penetration than unmodified peptides
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
Related skin conditionings
Same plant / compound family
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.