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Arecoline

CAS 63-75-2
5

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Arecoline is a natural alkaloid from the betel nut with significant toxicity—it is a known mutagen, reproductive toxicant, and is banned in EU cosmetics at ≥0.1%.

Arecoline (CAS 63-75-2) is the primary alkaloid in Areca catechu (betel nut). It is classified as a Substances of Very High Concern (SVHC) under EU REACH due to reproductive toxicity (Repr. 1B; H361) and mutagenicity (Muta. 2; H341). EU cosmetics regulation prohibits its use in cosmetic mixtures at concentrations ≥0.1%. It acts as a cholinergic agonist with systemic effects. PubChem safety score: 3, reflecting severe toxicity concerns.

Known concerns

  • Reproductive toxicant (H361)
  • Mutagen (H341)
  • SVHC under REACH
  • Cholinergic agonist with systemic effects
  • EU ban in cosmetics at ≥0.1%

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.