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Acetorphine

CAS 25333-77-1
5

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A potent opioid analgesic with structural similarity to morphine and etorphine, carrying the same severe safety concerns and regulatory prohibitions.

Acetorphine is a semi-synthetic opioid (the 3-acetyl derivative of morphine) with analgesic potency substantially greater than morphine. As an opioid receptor agonist with no cosmetic application history and a profile of severe safety concerns identical to other opioid analgesics, it is excluded from cosmetic formulations under the same regulatory framework that prohibits morphine and its derivatives. Its status as a controlled substance in all major jurisdictions confirms its unsuitability for cosmetic use.

Known concerns

  • Potent opioid agonist with no cosmetic function
  • Controlled substance status globally
  • No EU cosmetics authorisation
  • Severe respiratory depression risk

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.