5-Pyrimidinamine, 1,3-bis(2-ethylhexyl)hexahydro-5-methyl-
Other
Caution
CAS Number: 141-94-6
About 5-Pyrimidinamine, 1,3-bis(2-ethylhexyl)hexahydro-5-methyl-
An antimicrobial preservative (hexetidine) with broad-spectrum activity but significant skin, eye, and inhalation toxicity requiring strict concentration controls.
Detailed Analysis
Hexetidine is a broad-spectrum antimicrobial preservative used in some cosmetic formulations at a maximum EU CosIng permitted concentration of 0.1%. The extensive GHS hazard profile (H302, H312, H315, H319, H332, H335, H318) reflects its toxicity across multiple exposure routes. While approved as a cosmetic preservative within the stated limit, the compound's toxicity profile means it is not widely used and is subject to scrutiny under the EU Biocidal Products Regulation for broader antimicrobial claims.
Skin Benefits
- ✓ Provides antimicrobial preservation in cosmetic formulations
Known Concerns
- ⚠ Acute oral toxicity (H302)
- ⚠ Dermal and inhalation toxicity (H312, H332)
- ⚠ Skin and eye irritant (H315, H319, H318)
- ⚠ EU restricted to ≤0.1% as cosmetic preservative only
Safety Score
Caution
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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