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5-Pyrimidinamine, 1,3-bis(2-ethylhexyl)hexahydro-5-methyl-

CAS 141-94-6
36

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

An antimicrobial preservative (hexetidine) with broad-spectrum activity but significant skin, eye, and inhalation toxicity requiring strict concentration controls.

Hexetidine is a broad-spectrum antimicrobial preservative used in some cosmetic formulations at a maximum EU CosIng permitted concentration of 0.1%. The extensive GHS hazard profile (H302, H312, H315, H319, H332, H335, H318) reflects its toxicity across multiple exposure routes. While approved as a cosmetic preservative within the stated limit, the compound's toxicity profile means it is not widely used and is subject to scrutiny under the EU Biocidal Products Regulation for broader antimicrobial claims.

Skin benefits

  • Provides antimicrobial preservation in cosmetic formulations

Known concerns

  • Acute oral toxicity (H302)
  • Dermal and inhalation toxicity (H312, H332)
  • Skin and eye irritant (H315, H319, H318)
  • EU restricted to ≤0.1% as cosmetic preservative only

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.