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2-Ethylhexyl 4-(dimethylamino)benzoate / Padimate O (USAN:BAN)

CAS 21245-02-3
35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Padimate O (2-ethylhexyl 4-dimethylaminobenzoate) is a PABA derivative that absorbs UV radiation in the UVB range. Despite its UV-filtering efficacy, it is classified H360F (suspected of damaging fertility), placing it in Category 2 for reproductive toxicity under EU CLP regulation. This classification significantly restricts its use in cosmetic products, particularly in leave-on products such as sunscreens intended for consumer use. It was widely used in the 1980s but has been largely replaced.

Skin benefits

  • UVB radiation absorber
  • Used in sunscreen and UV-protective formulations (now limited)

Known concerns

  • Suspected reproductive toxicant (H360F, Category 2)
  • Skin irritant (H315)
  • Eye irritant (H319)
  • Respiratory irritant (H335)
  • Severely restricted or phased out in EU sunscreens

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.