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3-Hydroxy-N-(o-tolyl)-4-[(2,4,5-trichlorophenyl)azo]naphthalene-2-carboxamide

CAS 6535-46-2
35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Pigment Red 112, a halogenated azo pigment classified as a skin sensitizer (H317) and environmental hazard (H411), permitted only in rinse-off cosmetics in the EU.

Pigment Red 112 (CI 12370) is a dichloro-trichlorophenyl-azo naphthalene carboxamide used as a colorant in rinse-off cosmetic products. Its GHS hazard profile shows H317 (skin sensitization), H411 (aquatic toxicity), and H413 (persistent aquatic hazard). Under EU Regulation (EC) No 1223/2009 Annex III, it is restricted to rinse-off products only. The presence of multiple chlorine substituents on the azo-coupled aromatic system reduces but does not eliminate concern about biotransformation to sensitizing intermediates.

Skin benefits

  • Provides red coloration in rinse-off cosmetic formulations

Known concerns

  • Classified H317 skin sensitizer (EU CLP Regulation 1272/2008)
  • H411 aquatic toxic - harmful to aquatic organisms
  • H413 persistent aquatic hazard
  • Restricted to rinse-off products only per EU Annex III

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.