Conditioning Agent
SH-POLYPEPTIDE-15
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
A recombinant human TIMP-2 (Tissue Inhibitor of Metalloproteinases-2) analogue produced in E. coli that supports skin conditioning through matrix metalloproteinase inhibition.
sh-Polypeptide-15 is a recombinant human single-chain peptide of up to 220 amino acids, identical to human Tissue Inhibitor of Metalloproteinases-2 (TIMP-2), produced by fermentation in E. coli. TIMP-2 inhibits matrix metalloproteinases (MMPs) that degrade collagen and elastin, making it relevant for anti-aging cosmetics. It is not specifically restricted under EU cosmetics regulation, though its protein nature and biological activity require appropriate use concentration assessment.
Function
Skin benefits
- Anti-aging through MMP inhibition
- Supports extracellular matrix preservation
- Skin conditioning function
Known concerns
- Immunological activity warrants concentration control
- Bacterial expression requires purity and endotoxin assessment
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
Related conditioning agents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.