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Hair dye precursor

N,N-BIS(2-HYDROXYETHYL)-P-PHENYLENEDIAMINE SULFATE

CAS 54381-16-7
22

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A hydroxyethyl-modified p-phenylenediamine oxidative hair dye intermediate. Restricted in EU hair dye products with strict limits and warning labels, due to allergic contact dermatitis risk in the PPD family.

Skin benefits

  • Oxidative hair dye precursor in the PPD family
  • Produces controlled color development with couplers
  • Modified structure can offer slightly improved tolerance over parent PPD in some users

Known concerns

  • Belongs to the p-phenylenediamine chemical family with strong sensitization potential
  • Restricted in EU hair dye applications with concentration limits and labeling
  • Cross-reactivity with PPD allergy is well documented
  • Not permitted in eyelash or eyebrow products
  • Repeated exposure can trigger severe contact dermatitis

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.