N,N-bis(2-Chloroethyl)methylamine N-oxide and its salts
Other
Avoid
CAS Number: 126-85-2
About N,N-bis(2-Chloroethyl)methylamine N-oxide and its salts
A nitrogen mustard derivative with significant mutagenicity and carcinogenicity concerns that is not permitted in cosmetic products in most regulated markets.
Detailed Analysis
This compound bears structural alerts for genotoxicity consistent with nitrogen mustard alkylating agents, carrying EU hazard classifications H340 (germ cell mutagenicity) and H351 (carcinogenicity suspect). Under EU Cosmetics Regulation 1223/2009, substances with CMR Category 1B classifications are generally prohibited from cosmetic use unless specifically exempted and safety-assessed. The ingredient is not listed in any EU Annex, effectively barring its use in cosmetic formulations placed on the EU market.
Known Concerns
- ⚠ Suspected germ cell mutagen (H340)
- ⚠ Suspected carcinogen (H351)
- ⚠ Structural alerts for DNA alkylation
- ⚠ Not listed in EU Annexes — effectively prohibited in EU-market cosmetics
Safety Score
Avoid
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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