M-PHENYLENEDIAMINE
Colorant
Avoid
CAS Number: 108-45-2
About M-PHENYLENEDIAMINE
A hair-dye intermediate that the EU banned — it cross-reacts with PPD allergies and showed genotoxicity signals in testing.
Detailed Analysis
meta-Phenylenediamine (m-PPD, 1,3-diaminobenzene, CAS 108-45-2) is a diamine formerly used as a component of oxidative hair dyes. In the EU post-2003 hair-dye safety review, the SCCS evaluated it and it was added to Annex II (prohibited) of the Cosmetics Regulation because the safety dossier did not support continued use — genotoxicity signals in in-vitro assays and contact-sensitization liability were central concerns. It is a recognised cross-reactor with p-phenylenediamine (PPD), so consumers with PPD allergy will typically react to it as well. There is no legal cosmetic use in the EU.
Skin Benefits
- ✓ Historical hair-dye use only
Known Concerns
- ⚠ EU Annex II prohibited
- ⚠ Cross-reacts with PPD allergy
- ⚠ In-vitro genotoxicity signals
- ⚠ Contact sensitizer
Safety Score
Avoid
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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Download LuxSenseThis information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.