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3-ASCORBYLMETHYLCARBONYL GLYCYL TRI-T-BUTYL TRYPTOPHANAMIDE

87

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A triple-protected peptide conjugate of vitamin C (ascorbic acid) with glycine and tryptophan designed for superior skin penetration and stability, with an excellent expected safety profile.

This compound is a sophisticated vitamin C (ascorbic acid) derivative where the C3 hydroxyl is protected by a methylcarbonyl glycyl tri-t-butyl tryptophanamide moiety. Unlike ascorbic acid itself, such derivatives are stable in cosmetic formulations and upon skin absorption can liberate active vitamin C. Vitamin C in its various forms is one of the most extensively studied and safest cosmetic actives. The glycine and tryptophan fragments — protected as t-butyl carbamate and amide — are fragments of the amino acid chemistry used throughout pharmacology and cosmetics with no independent toxicity. The high molecular weight and protected nature makes systemic absorption unlikely.

Skin benefits

  • Antioxidant protection from stable vitamin C delivery
  • Potential collagen synthesis support
  • Brightening and anti-aging skin benefits
  • Stable in cosmetic formulations avoiding oxidation problems of free ascorbic acid

Known concerns

  • Novel derivative — limited standalone safety data but well-supported by parent compound toxicology
  • No EU CosIng specific restriction entries

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.