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2-(HYDROXYMETHOXYMETHOXY)-P-PHENYLENEDIAMINE

CAS 2839861-17-3
48

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

2-(hydroxymethoxymethoxy)-P-Phenylenediamine is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

This p-phenylenediamine (PPD) derivative is structurally modified with a hydroxymethoxymethoxy (-O-CH2-O-CH2-OH) substituent at the para position relative to the primary amine. Like other PPD derivatives, it functions as a primary intermediate in oxidative hair coloration, coupling with diamines and resorcinols to form colored polyermic dyes. The EU Cosmetics Regulation Annex III (part 2) lists p-phenylenediamine and its derivatives with specific concentration limits and required labelling. These hair dye intermediates are recognized contact allergens and require cautionary statements in finished product labelling.

Known concerns

  • Skin sensitizer - hair dye intermediate allergen class
  • EU Annex III restricted (concentration limits apply)
  • Required labelling as skin sensitization hazard

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.