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2-ETHYL-3,(5 OR 6)-DIMETHYLPYRAZINE

CAS 27043-05-6
68

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

2-ethyl-3,(5 or 6)-dimethylpyrazine is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

2-Ethyl-3,(5 or 6)-dimethylpyrazine is a pyrazine derivative occurring naturally in cocoa, coffee, and grilled foods; used as a flavor and fragrance ingredient. Pyrazines in cosmetic use are typically limited to leave-on concentrations below 0.01% due to potential for skin and respiratory irritation. The ingredient is listed on FDA and EU flavor substance lists (FEMA GRAS) for food use; however, cosmetic topical application has less regulatory precedent. SCCS guidance notes insufficient data for pyrazine cosmetic safety but no immediate concern at trace levels.

Known concerns

  • Limited cosmetic safety data - primarily food use
  • May cause skin/eye irritation at higher concentrations
  • Pyrazines can be respiratory irritants in aerosol products

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.