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2-(2-(2-METHOXYETHOXY)ETHOXY)-P-PHENYLENEDIAMINE

CAS 93881-99-3
28

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

2-(2-(2-Methoxyethoxy)ethoxy)-P-Phenylenediamine is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

This compound incorporates a triethylene glycol monomethyl ether substituent on the phenylenediamine core, enhancing solubility and modifying the dyeing kinetics. The polyethylene glycol-type chain reduces the compound's volatility but does not eliminate its sensitization potential. Regulation 1223/2009 Annex III restricts aromatic amine hair dye intermediates including this class of PEGylated derivatives due to insufficient long-term safety data and documented skin sensitization cases. Typical EU restrictions limit ready-to-use hair dye concentrations to 2% maximum, with required pre-test warnings and professional guidance recommendations.

Known concerns

  • Documented skin sensitization risk
  • Limited historical safety data for long-term use
  • Potential for systemic absorption through scalp
  • Reactive intermediate formation during oxidative coupling

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.