Fragrance
TRIMETHYLPYRAZINE
Safety score · 0–100
Good
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
A nitrogen heterocycle giving roasted, cocoa, and coffee notes — naturally present in those foods and FEMA GRAS-approved as a flavoring.
Trimethylpyrazine (CAS 14667-55-1) is a naturally occurring pyrazine formed during thermal Maillard-type processes; it is abundant in roasted coffee, cocoa, and cooked meats. Regulatory bodies have evaluated it as a flavoring: FEMA GRAS listing covers oral use, and JECFA has reviewed alkylpyrazines as a group without safety concerns at normal use levels. Fragrance use is minor by volume and occurs at low percentages. No significant GHS hazards beyond mild eye/skin irritation at neat concentrations; not a classified sensitizer and not an EU Annex III declarable allergen.
Function
Skin benefits
- Roasted/nutty fragrance note
- Natural dietary presence
Known concerns
- Fragrance allergen load consideration
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
Related fragrances
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.