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Hair Conditioning

SR-(METHIONYL HEXAPEPTIDE-40 OLIGOPEPTIDE-231 S-SPIDER POLYPEPTIDE-1) FORMATE

45

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A very large (1190 amino acid) recombinant fusion peptide containing a spider-protein domain, esterified with formate — marketed for hair and lash conditioning. Size, sequence and chemistry all raise safety questions.

Function

HAIR CONDITIONINGEYELASH CONDITIONING

Skin benefits

  • Marketed for hair and eyelash conditioning

Known concerns

  • 1190-amino-acid recombinant fusion lacks public dossier
  • Spider-derived peptide sequence with unknown allergen profile
  • Formate esterification adds reactive species
  • Endotoxin control critical for E. coli protein

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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Same plant / compound family

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SR-(METHIONYL HEXAPEPTIDE-40 DECAPEPTIDE-66 METHIONYL SPIDER POLYPEPTIDE-3 OLIGOPEPTIDE-235)
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SR-(METHIONYL HEXAPEPTIDE-40 SACCHAROMYCES POLYPEPTIDE-2 SH-POLYPEPTIDE-134)
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SR-(METHIONYL HEXAPEPTIDE-40 SH-POLYPEPTIDE-47 SH-POLYPEPTIDE-158)
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Find SR-(METHIONYL HEXAPEPTIDE-40 OLIGOPEPTIDE-231 S-SPIDER POLYPEPTIDE-1) FORMATE in your products.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.