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Conditioning Agent

SOPHOCARPINE

CAS 6483-15-4
40

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A toxic quinolizidine alkaloid from Sophora plants — classified as 'Danger' for acute oral toxicity. Used in skin conditioning at very low doses.

Sophocarpine (CAS 6483-15-4) is a quinolizidine alkaloid found in Sophora flavescens (ku shen) and related legumes. GHS classification H301 (toxic if swallowed, 100%) with signal word 'Danger' indicates significant acute oral toxicity (LD50 likely < 300 mg/kg). While used in traditional Chinese medicine for anti-inflammatory effects, the acute toxicity classification limits its cosmetic application to very low concentrations. No EU restrictions listed, but the Danger signal word warrants careful dose management.

Function

SKIN CONDITIONING

Skin benefits

  • Anti-inflammatory potential at safe concentrations

Known concerns

  • Toxic if swallowed (H301) — Danger
  • Alkaloid with significant systemic toxicity
  • Narrow therapeutic/cosmetic window

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.