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Skin Conditioning

(SH-OLIGOPEPTIDE-78 DI-(S-SILKWORM HEXAPEPTIDE-1)) PEPTIDES

68

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A conjugate of bioengineered SH-Oligopeptide-78 (a growth-factor-like peptide) with silkworm hexapeptide. Novel; thin public safety data.

This INCI covers a multi-part peptide preparation combining SH-Oligopeptide-78 (a bioengineered "synthetic human" oligopeptide positioned as a growth-factor analog in cosmetics) with di-substitution by silkworm-derived synthetic hexapeptide sequences. Cosmetic rationale centers on combined signaling for cell renewal and barrier conditioning. Growth-factor-analog peptides sit in a regulatory grey zone and have attracted scrutiny from FDA and some EU authorities. No CIR/SCCS review exists. Use at very low concentrations (trace levels) is typical. Default-cautious scoring applies given limited public data.

Skin benefits

  • SH-oligopeptide-78 is a bioengineered signal peptide (analog to IGF-1 or similar growth factor)
  • Silkworm hexapeptide brings additional conditioning signal
  • Low cosmetic use concentration
  • Novel anti-aging mechanism

Known concerns

  • Bioengineered growth-factor-analog peptides have regulatory ambiguity
  • No CIR or SCCS review
  • Limited clinical efficacy evidence
  • Supplier-driven safety documentation

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.