R-(TETRAPEPTIDE-69 SH-POLYPEPTIDE-126 HEXAPEPTIDE-40)
Conditioning Agent
Good
About R-(TETRAPEPTIDE-69 SH-POLYPEPTIDE-126 HEXAPEPTIDE-40)
A larger recombinant fusion peptide combining tetrapeptide, human polypeptide, and hexapeptide sequences for skin conditioning and protection, requiring standard safety assessment.
Detailed Analysis
R-(Tetrapeptide-69 sh-Polypeptide-126 Hexapeptide-40) is a recombinant fusion peptide produced in E. coli, combining three peptide components into a 355-amino acid chain. No EU restrictions are listed. The larger size of this fusion protein (355 aa) suggests lower skin permeability compared to smaller peptides. Tetrapeptide-69 sequences are often associated with antioxidant or anti-aging activity, while sh-Polypeptide-126 relates to growth factor-like sequences. The II/416 restriction is not listed, indicating this particular combination has not been flagged for specific SCCS review. Standard recombinant protein safety testing (purity, endotoxin, sensitization) is required.
What It Does
Skin Benefits
- ✓ Skin conditioning
- ✓ Skin protecting
Known Concerns
- ⚠ Larger recombinant protein — requires comprehensive purity and endotoxin testing
Safety Score
Good
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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