P-METHYLAMINOPHENOL
Other
Caution
CAS Number: 150-75-4
About P-METHYLAMINOPHENOL
An aminophenol hair dye intermediate used in oxidative coloration; restricted under EU Annex III (III/223) with concentration limits due to skin sensitization and toxicity concerns.
Detailed Analysis
P-Methylaminophenol (also known as 4-methylaminophenol) functions as a primary intermediate in oxidative hair dye formulations, developing color through oxidative polymerization. The methylaminophenol structure creates toxicological concerns related to methemoglobin formation and potential genotoxicity. The EU Cosmetics Regulation 1223/2009 Annex III listing (reference III/223) imposes specific conditions on its use, limiting concentrations and requiring specific purity criteria to minimize contamination from related aniline derivatives. The SCCS has requested additional toxicological data for complete safety assessment of this class of hair dye intermediates.
Known Concerns
- ⚠ EU Annex III restriction (III/223) with concentration limits
- ⚠ Methemoglobin formation potential
- ⚠ Skin sensitization and allergic contact dermatitis
- ⚠ Possible genotoxic impurities from aniline derivatives
Safety Score
Caution
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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