O-METHOXYCINNAMALDEHYDE

Fragrance

55

Moderate

CAS Number: 1504-74-1

About O-METHOXYCINNAMALDEHYDE

A fragrance aldehyde related to cinnamon — causes skin irritation, eye irritation, and respiratory irritation. Cinnamaldehydes are known sensitizers, so be cautious.

Detailed Analysis

o-Methoxycinnamaldehyde (C₁₀H₁₀O₂, MW 162.18, CID 641298), also known as (E)-3-(2-methoxyphenyl)prop-2-enal, is a methoxylated cinnamaldehyde derivative used in perfumery. GHS classifications include H315 (skin irritation, 100%), H319 (serious eye irritation, 100%), and H335 (respiratory irritation, 100%). Cinnamaldehydes as a class are well-known skin sensitizers — cinnamal itself is an EU Annex III fragrance allergen. The methoxy substitution may slightly reduce but does not eliminate sensitization potential.

What It Does

PERFUMING

Known Concerns

  • ⚠ Causes skin irritation (H315)
  • ⚠ Causes serious eye irritation (H319)
  • ⚠ May cause respiratory irritation (H335)
  • ⚠ Cinnamaldehyde derivatives are known skin sensitizers
  • ⚠ Related to EU-listed fragrance allergen cinnamal

Safety Score

55

Moderate

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.