Skip to content

Preservative

NISIN

CAS 1414-45-5
82

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A small natural antimicrobial peptide (E234) produced by Lactococcus lactis — used as a food preservative for decades and now as a cosmetic preservative. Excellent safety record, mostly active against Gram-positive bacteria.

Skin benefits

  • Natural broad-spectrum antimicrobial peptide
  • Particularly active vs Gram-positive bacteria
  • Food-grade and GRAS safety status (E234)
  • Effective at low concentrations

Known concerns

  • Limited activity against Gram-negative bacteria and fungi
  • Possible immune-stimulation in sensitised individuals
  • Activity drops at pH > 7
  • Dairy-fermentation origin — allergen carry-over possible

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Related preservatives

82
CALCIUM SORBATE
Preservative
 82
P-ANISIC ACID
Preservative
 82
POLYLYSINE HBR
Preservative
 82
SODIUM LEVULINATE
Preservative
 80
CALCIUM PROPIONATE
Preservative
 80
CAPRYLHYDROXAMIC ACID
Preservative
 80
ETHYLHEXYLGLYCERIN
Preservative
 80
HEPTYLGLYCERIN
Preservative

Check your shelf

Find NISIN in your products.

Scan any cosmetic product with LuxSense to see if it contains NISIN and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.