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Conditioning Agent

NAPROXEN

CAS 22204-53-1
35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Naproxen is a pharmaceutical NSAID used in cosmetics for skin conditioning but is subject to EU restrictions as a drug-like substance with systemic toxicity concerns.

Naproxen (CAS 22204-53-1, (S)-2-(6-methoxy-2-naphthyl)propionic acid) is a non-steroidal anti-inflammatory drug (NSAID). While it has skin conditioning properties, it is a pharmaceutical substance with known systemic toxicity (gastrointestinal, cardiovascular, renal effects). The EU cosmetics regulation flags substances that deplete the ozone layer for restrictions, and drug-like substances with systemic profiles are generally incompatible with cosmetic use in the EU. Naproxen use in cosmetics is highly restricted and discouraged.

Function

SKIN CONDITIONING

Skin benefits

  • Skin conditioning

Known concerns

  • Pharmaceutical NSAID with systemic toxicity
  • Gastrointestinal risk
  • Cardiovascular risk
  • Not approved as cosmetic active in EU

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.