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oral-care antimicrobial

N,N',N'-Tris(polyoxyethylene)-N-hexadecylpropylenediamine dihydrofluoride

40

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

An ethoxylated hexadecyl propylenediamine dihydrofluoride historically used in oral-care products as a combined antimicrobial and fluoride-delivery surfactant, with limited cosmetic safety data.

Skin benefits

  • Used historically in oral-care formulations as a fluoride-delivery agent
  • Provides antimicrobial and anti-plaque effect on teeth
  • Combines surfactant and fluoride donor functions

Known concerns

  • High molecular complexity with limited cosmetic-specific safety data
  • Fluoride counterion requires careful dose control to avoid fluorosis
  • PEG chains may carry trace ethylene oxide or 1,4-dioxane
  • Quaternary amine structure raises mild irritation potential

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.