N,N-Dimethylaniline
Other
Caution
CAS Number: 121-69-7
About N,N-Dimethylaniline
N,N-Dimethylaniline is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.
Detailed Analysis
N,N-Dimethylaniline (DMA, CAS 121-69-7) is an aromatic tertiary amine used as a solvent and intermediate in chemical synthesis. It is listed in EU Annex III (substances subject to restrictions) with a maximum allowable concentration in cosmetic products. The SCCS has expressed concern over dermal absorption leading to systemic toxicity, including methemoglobin formation (a condition where hemoglobin cannot carry oxygen properly), liver enzyme induction, and reproductive effects. IARC classifies it as Group 3 (not classifiable as to carcinogenicity to humans), but the combined toxicity profile makes it a restricted ingredient in cosmetic formulations within the EU market.
Known Concerns
- ⚠ EU Annex III restricted due to dermal absorption risk
- ⚠ Methemoglobinemia induction on systemic absorption
- ⚠ Hepatotoxicity (liver enzyme induction)
- ⚠ Reproductive and developmental toxicity at high doses
- ⚠ IARC Group 3 (data insufficient for carcinogen classification)
Safety Score
Caution
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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Download LuxSenseThis information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.