N,N-(Dimethylamino)thioacetamide hydrochloride
Other
Avoid
CAS Number: 27366-72-9
About N,N-(Dimethylamino)thioacetamide hydrochloride
N,N-(Dimethylamino)thioacetamide hydrochloride is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.
Detailed Analysis
N,N-(Dimethylamino)thioacetamide hydrochloride is the hydrochloride salt of a thioacetamide bearing a dimethylamino group. Thioacetamides are a well-known class of toxicological concern due to their metabolic conversion to acetamides and their liver toxicity (H372 STOT). The EU H360D classification (Category 1B reproductive toxicant) and H410 (aquatic chronic toxicity) further restrict this compound's cosmetic applicability. While not specifically listed in EU Annex II, the hazard profile is sufficiently severe that cosmetic use would be contraindicated by any responsible formulation practice.
Known Concerns
- ⚠ H360D: May damage the unborn child (Category 1B reproductive toxicant)
- ⚠ H410: Very toxic to aquatic life with long-lasting effects
- ⚠ H302/H312/H332: Acute oral, dermal, and inhalation toxicity
- ⚠ Thioacetamide structural alert for hepatotoxicity and genotoxicity
- ⚠ Not appropriate for cosmetic use given hazard profile
Safety Score
Avoid
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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