N,N-Dimethylacetamide

Other

38

Caution

CAS Number: 127-19-5

About N,N-Dimethylacetamide

N,N-Dimethylacetamide is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Detailed Analysis

N,N-Dimethylacetamide (DMAC, CAS 127-19-5) is a polar aprotic solvent used in some cosmetic raw material manufacturing processes and occasionally in nail polish and coating formulations. It is classified by IARC as Group 2A (probable human carcinogen) and is listed as an EU REACH Substance of Very High Concern (SVHC) due to its reproductive toxicity (teratogenicity). The SCCS has noted concerns regarding systemic absorption through skin. Under EU Regulation 2023/1499, DMAC is restricted in cosmetic products, and its maximum workplace exposure limit is regulated. Use in final cosmetic formulations is highly restricted or prohibited in the EU.

Known Concerns

  • ⚠ EU REACH SVHC — reproductive toxicity (teratogenicity)
  • ⚠ IARC Group 2A probable carcinogen
  • ⚠ SCCS concern regarding dermal absorption
  • ⚠ EU-regulated workplace exposure limit
  • ⚠ Restricted in cosmetic products under EU Regulation 2023/1499

Safety Score

38

Caution

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.