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Pharmaceutical antihistamine (prohibited in cosmetics)

N'-Benzyl-N,N-dimethyl-N'-pyridin-2-ylethylenediammonium maleate

CAS 58044-99-8
18

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Pharmacologically active pyridine-ethylenediamine antihistamine in the mepyramine family, given as a maleate salt. It is a drug substance with no cosmetic function and a recognised contact and photosensitisation risk.

Skin benefits

  • Pharmaceutical antihistamine (mepyramine/pyrilamine analogue)
  • Not a cosmetic ingredient

Known concerns

  • Systemic pharmacological activity (H1-antagonist class)
  • Risk of sensitisation and photosensitivity
  • No cosmetic safety dossier
  • EU bans drug actives from cosmetics

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.