KALLIKREIN
Exfoliant
Caution
CAS Number: 9001-01-8
About KALLIKREIN
A serine protease enzyme (CAS 9001-01-8). Biologically active — useful for exfoliation but raises barrier/irritation concerns if misused.
Detailed Analysis
Kallikrein (CAS 9001-01-8) is a family of serine proteases; in skin biology kallikreins 5 and 7 regulate desquamation, and their overactivity is implicated in Netherton syndrome and atopic dermatitis. As a cosmetic ingredient, applied kallikrein is marketed for gentle enzymatic turnover. Because active proteases can disrupt barrier proteins (corneodesmosomes), misformulation or elevated activity carries a real risk of stinging, redness and impaired barrier function. Historically sourced from porcine pancreas; recombinant and synthetic versions exist. No specific EU restriction, but kallikrein-type proteases are treated cautiously by CIR and formulators.
What It Does
Skin Benefits
- ✓ Serine protease that helps with gentle exfoliation
- ✓ Used in specialty peeling/turnover products
- ✓ Localised activity only
Known Concerns
- ⚠ Proteolytic enzyme — irritation and barrier-damage risk
- ⚠ Animal/human origin complications
- ⚠ Kallikrein-family overactivity linked to skin disease (Netherton syndrome)
Safety Score
Caution
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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