GALEGA OFFICINALIS EXTRACT

Conditioning Agent

45

Caution

CAS Number: 84650-07-7

About GALEGA OFFICINALIS EXTRACT

Goat's Rue extract contains galegine, a hypoglycaemic alkaloid with documented animal toxicity and limited human safety data, making it a higher-concern botanical for cosmetic formulators.

Detailed Analysis

Galega officinalis contains galegine (isoamyleneguanidine), a toxic alkaloid with hypoglycaemic and goitrogenic effects documented in livestock poisoning. Galegine has been studied for antidiabetic potential but shows a narrow therapeutic index. EU Regulation 1223/2009 does not specifically restrict this ingredient; however, given the known toxicity of galegine and its structural similarity to metformin, use in leave-on cosmetics warrants caution and concentration restriction below 0.1%. Not recommended for sensitive skin formulations.

What It Does

SKIN CONDITIONING

Skin Benefits

  • ✓ Antimicrobial (historical insecticidal use)
  • ✓ Skin conditioning

Known Concerns

  • ⚠ Contains galegine with documented hypoglycaemic toxicity in animals
  • ⚠ Narrow therapeutic index
  • ⚠ Goitrogenic effects
  • ⚠ Not recommended for leave-on products at >0.1%

Safety Score

45

Caution

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.