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Banned Substance

CHELIDONINE

CAS 476-32-4
15

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A toxic alkaloid from greater celandine (Chelidonium majus). Linked to liver injury in oral herbal use and DNA damage in lab studies — not suitable for cosmetics.

Skin benefits

  • Historical herbal use — minimal modern cosmetic relevance

Known concerns

  • Toxic benzophenanthridine alkaloid from greater celandine
  • Hepatotoxicity reports from oral herbal use
  • DNA-damaging in vitro studies
  • EU Annex II lists Chelidonium majus alkaloids as restricted

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.