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Signal / soothing peptide

ACETYL SH-PENTAPEPTIDE-1

82

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A stabilized thymopentin analogue peptide that calms inflammation and supports collagen production. Best for soothing aging or reactive skin, though independent efficacy data is still limited.

Skin benefits

  • Mimics thymopoietin, a natural immune-modulating peptide
  • Helps reduce inflammation by suppressing IL-8 release
  • Supports collagen and elastin synthesis for firmer-looking skin
  • Reduces MMP-9 activity that breaks down structural proteins

Known concerns

  • Peptide stability in finished formulas depends on pH and packaging
  • Most efficacy data comes from supplier studies rather than independent trials
  • Costly raw material can be under-dosed in budget products

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Same plant / compound family

66
ACETYL SH-PENTAPEPTIDE-14 SP AMIDE
Skin Conditioning
 80
ACETYL SH-PENTAPEPTIDE-17 SP LYSINE AMIDE
Skin Conditioning

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.