6-(Piperidinyl)-2,4-pyrimidinediamine-3-oxide (Minoxidil (INN)) and its salts
Safety score · 0–100
Caution
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
A potent vasodilator drug listed in EU Annex III for restricted hair-growth cosmetic use, carrying a pubchem_safety_score of 8 reflecting its pharmaceutical nature.
Minoxidil is listed in EU Annex III/1 (hair growth substances) with specific restrictions on its use in cosmetic products intended for hair growth stimulation. Despite its potent pharmacological vasodilatory action, it is permitted at low concentrations in scalp treatments in some EU member states, though it remains a prescription-drug-level ingredient with systemic cardiovascular risk if improperly used. Its pubchem_safety_score of 8 confirms its drug-like hazard profile.
Skin benefits
- Promotes hair growth by vasodilation of scalp blood vessels (pharmaceutical use)
Known concerns
- Drug-level potency — cardiovascular effects with systemic absorption
- Restricted under EU Annex III for hair growth products
- Not for general cosmetic use
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.