4,4'-Methylenedianiline

2

Avoid

CAS Number: 101-77-9

About 4,4'-Methylenedianiline

4,4'-methylenedianiline is a cosmetic ingredient. Exercise caution due to limited available safety data.

Detailed Analysis

4,4'-Methylenedianiline is listed in Annex II of EU Regulation (EC) No 1223/2009 and is classified as a Category 1B carcinogen under CLP Regulation (EC) No 1272/2008. It was formerly used in polyurethane polymer synthesis and epoxy resin systems. MDA is readily absorbed through skin and is hepatotoxic. It also functions as a strong contact allergen, making it particularly dangerous in topical products.

Known Concerns

  • ⚠ Prohibited in EU cosmetics (Annex II)
  • ⚠ Category 1B carcinogen (CLP)
  • ⚠ Confirmed skin sensitizer
  • ⚠ Hepatotoxic
  • ⚠ Readily absorbed through skin

Safety Score

2

Avoid

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.