4,4'-ISOPROPYLIDENEDIPHENOL

12

Avoid

CAS Number: 80-05-7

About 4,4'-ISOPROPYLIDENEDIPHENOL

Bisphenol A (BPA) is a high-production-volume chemical banned from cosmetics in the EU due to confirmed reproductive toxicity and endocrine-disrupting properties.

Detailed Analysis

4,4'-Isopropylidenediphenol — commonly known as BPA — is classified as a CMR 1B substance under EU Regulation 1272/2008 (CLP), meaning it is presumed to cause cancer, gene mutations, and reproductive toxicity. It is listed in EU Annex II (entry 1176) prohibiting its use in cosmetic products. The extensive hazard profile includes H317 (skin sensitisation), H318 (serious eye damage), H360F (fertility damage), and H410 (very toxic to aquatic life).

Known Concerns

  • ⚠ Endocrine disruption
  • ⚠ Reproductive toxicity (CMR 1B)
  • ⚠ Skin sensitisation
  • ⚠ Eye damage
  • ⚠ Aquatic toxicity
  • ⚠ EU Annex II banned substance

Safety Score

12

Avoid

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.