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4,4'-Dihydroxy-3,3'-(3-methylthiopropylidene) dicoumarin

CAS -
35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

4,4'-Dihydroxy-3,3'-(3-methylthiopropylidene) dicoumarin is a cosmetic ingredient used in product formulation. Exercise caution due to limited available safety data.

This dicoumarin structure features two coumarin units connected by a thioether linkage at the 3 and 3' positions with 4-hydroxy and 3-methylthiopropylidene substituents. Dicoumarin-type compounds are known for their vitamin K antagonist (anticoagulant) activity, similar to the banned rodenticide warfarin (which was itself developed from dicumarol, a natural coumarin dimer). The structural similarity raises serious concerns about potential blood-thinning effects if absorbed through skin. This class of compounds should not be used in cosmetic formulations intended for dermal application due to systemic health risks.

Known concerns

  • Potential anticoagulant activity (vitamin K antagonist)
  • Structural alert for hemorrhagic risk
  • Dicoumarin-type compounds have drug-like effects
  • Should not be used in cosmetics
  • No established safe cosmetic use

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.