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Banned Substance

2-Chloro-6-methylpyrimidin-4-yldimethylamine (crimidine-ISO)

CAS 535-89-7
1

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Crimidine is a banned rodenticide that causes lethal seizures by blocking vitamin B6 metabolism. Listed in EU Annex II — has no legitimate cosmetic use whatsoever.

Skin benefits

  • Has only ever been used as a rodenticide

Known concerns

  • EU Annex II banned in cosmetics
  • Acutely toxic rodenticide (LD50 ~1 mg/kg)
  • Convulsant — antagonist of pyridoxal phosphate
  • Wholly unsuitable for topical application

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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Check your shelf

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.