2,4,6-TRIMETHYL-3-CYCLOHEXENECARBALDEHYDE

28

Avoid

CAS Number: 1423-46-7

About 2,4,6-TRIMETHYL-3-CYCLOHEXENECARBALDEHYDE

A highly sensitizing aldehyde with multiple hazard statements including respiratory sensitization (H334), making it a significant concern for cosmetic formulations.

Detailed Analysis

This trimethylcyclohexenecarbaldehyde carries a particularly concerning set of hazard statements: H317 (skin sensitization), H315 (skin irritation), H319 (eye irritation), H334 (may cause allergy or asthma symptoms if inhaled - respiratory sensitizer), H400 (very toxic to aquatic life), H412 (harmful to aquatic life). The combination of skin AND respiratory sensitization potential is especially significant, as respiratory allergens often pose greater societal health burden. The aldehyde functional group combined with the unsaturated ring structure creates a highly reactive Michael acceptor, explaining its strong sensitizing capacity.

Known Concerns

  • H317 skin sensitization
  • H315 skin irritation
  • H319 eye irritation
  • H334 respiratory sensitization (asthma risk)
  • H400/H412 aquatic toxicity
  • Dual skin + respiratory sensitization

Safety Score

28

Avoid

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.