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Banned Substance

16-ALPHA ETHYL ESTRADIOLCARBOXYLATE

CAS 345294-78-2
8

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

An estradiol-class steroidal carboxylate with hormonal activity. Estrogens are prohibited in EU cosmetics under Annex II — this substance must not be used in cosmetic formulations.

Function

SKIN CONDITIONING - EMOLLIENTSKIN CONDITIONINGSKIN PROTECTING

Skin benefits

  • Primarily a processing aid

Known concerns

  • Steroidal estrogen analog — endocrine-disrupting potential
  • Estrogenic chemistry not permitted in EU cosmetic products
  • Systemic absorption from topical use is plausible
  • Reproductive toxicity concerns

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.