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1-N-Methylmorpholiniumpropylamino-4-hydroxyanthraquinone, methyl sulfate

CAS 38866-20-5
52

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

An anthraquinone-derived hair dye with a quaternary ammonium morpholinium substituent, this compound is used as a semi-permanent violet-blue direct dye and is restricted in the EU to a maximum of 0.5% in rinse-off hair dye formulations.

This anthraquinone dye (a hydroxyanthraquinone derivative) functions as a direct hair dye providing violet to blue tones in semi-permanent color formulations. The quaternary ammonium morpholinium moiety increases water solubility and cationic character. EU CosIng lists this substance under Annex III restrictions with a specific concentration limit of 0.5% maximum. Anthraquinone dyes are generally considered less allergenic than para-phenylenediamine derivatives, though the morpholinium substituent introduces mild sensitization potential.

Skin benefits

  • Provides semi-permanent violet-blue hair coloration
  • Direct dye — no oxidation step required
  • Water-soluble cationic dye deposits on damaged hair cuticle

Known concerns

  • EU Annex III restricted — 0.5% maximum concentration
  • Rinse-off products only — not for leave-on skin application
  • Mild sensitization potential from anthraquinone chromophore
  • Quaternary ammonium may cause irritation in broken skin

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.