1,3,5-Tris(oxiranylmethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione (TGIC)

22

Avoid

CAS Number: 2451-62-9

About 1,3,5-Tris(oxiranylmethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione (TGIC)

A highly toxic epoxy resin with mutagenic, carcinogenic, and respiratory sensitization concerns, explicitly restricted in EU consumer products.

Detailed Analysis

1,3,5-Tris(oxiranylmethyl)-1,3,5-triazine-2,4,6-(1H,3H,5H)-trione, known as TGIC (CAS 2451-62-9), is a trifunctional epoxy resin. Extensive GHS hazard statements include H301 (toxic if swallowed), H317 (may cause skin sensitization), H318 (causes serious eye damage), H331 (toxic if inhaled), H340 (may cause genetic defects), H361 (suspected of damaging fertility or unborn child), H370 (causes damage to organs), H372 (causes damage to organs through prolonged exposure), H373, H315, H319, H334 (may cause allergy or asthma symptoms if inhaled), H412 (harmful to aquatic life). TGIC is restricted in EU under REACH regulations for consumer products due to its mutagenic and reproductive toxicity. It is not listed for cosmetic use in CosIng. Use in personal care is prohibited.

Known Concerns

  • ⚠ Mutagenic (H340)
  • ⚠ Reproductive toxicity (H361)
  • ⚠ Skin sensitization (H317)
  • ⚠ Respiratory sensitization (H334)
  • ⚠ Organ toxicity (H370, H372)
  • ⚠ Acute toxicity (H301, H331)

Safety Score

22

Avoid

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.