1,3,5-Tris(oxiranylmethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione (TGIC)
Safety score · 0–100
Caution
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
A highly toxic epoxy resin with mutagenic, carcinogenic, and respiratory sensitization concerns, explicitly restricted in EU consumer products.
1,3,5-Tris(oxiranylmethyl)-1,3,5-triazine-2,4,6-(1H,3H,5H)-trione, known as TGIC (CAS 2451-62-9), is a trifunctional epoxy resin. Extensive GHS hazard statements include H301 (toxic if swallowed), H317 (may cause skin sensitization), H318 (causes serious eye damage), H331 (toxic if inhaled), H340 (may cause genetic defects), H361 (suspected of damaging fertility or unborn child), H370 (causes damage to organs), H372 (causes damage to organs through prolonged exposure), H373, H315, H319, H334 (may cause allergy or asthma symptoms if inhaled), H412 (harmful to aquatic life). TGIC is restricted in EU under REACH regulations for consumer products due to its mutagenic and reproductive toxicity. It is not listed for cosmetic use in CosIng. Use in personal care is prohibited.
Known concerns
- Mutagenic (H340)
- Reproductive toxicity (H361)
- Skin sensitization (H317)
- Respiratory sensitization (H334)
- Organ toxicity (H370, H372)
- Acute toxicity (H301, H331)
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.