Yohimbine and its salts
Other
Avoid
CAS Number: 146-48-5
About Yohimbine and its salts
An indole alkaloid from Yohimbe bark with alpha-2 adrenergic antagonist activity, used in sexual enhancement products but prohibited in cosmetic products in the EU at concentrations above 0.1%. Its stimulant and vasodilatory effects present cardiovascular risks making it unsuitable for cosmetic skin care.
Detailed Analysis
Yohimbine (CAS 146-48-5) is an alkaloid extracted from the bark of the African tree Pausinystalia yohimbe, functioning as a selective alpha-2 adrenergic receptor antagonist causing vasodilation and increased peripheral blood flow. It is listed in EU Cosmetics Regulation (EC) No 1223/2009 Annex II (prohibited substances) for cosmetic use above 0.1% concentration. The SCCS and other regulatory bodies have noted concerns including cardiovascular effects (tachycardia, hypertension at high doses), CNS stimulation, and potential drug interactions. Its presence in cosmetic databases reflects prohibition rather than permitted use. The margin of safety for topical application has not been established, and cardiovascular absorption from topical use is a documented concern. No legitimate cosmetic skin conditioning function exists for this ingredient.
Known Concerns
- ⚠ EU Annex II prohibition at ≥0.1% in cosmetics
- ⚠ Cardiovascular effects — tachycardia, hypertension, arrhythmia risk
- ⚠ CNS stimulation and drug interaction concerns
- ⚠ No established safe topical cosmetic use
Safety Score
Avoid
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
Check your products for Yohimbine and its salts
Scan any cosmetic product to see if it contains this ingredient and get a full safety breakdown.
Download LuxSenseThis information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.