KAVALACTONES

Other

28

Avoid

About KAVALACTONES

Active lactone compounds derived from kava (Piper methysticum) root with documented concerns around hepatotoxicity and drug interaction potential, limiting their use in EU cosmetics.

Detailed Analysis

Kavalactones are the pharmacologically active constituents of kava (Piper methysticum), a plant native to the Pacific Islands. The EU has raised concerns about kava-containing products due to documented hepatotoxicity (liver injury including hepatitis and cirrhosis), leading to a ban on kava in food and food supplements in the EU (EC 2002/2321). For cosmetics, kavalactones are not explicitly listed in EU Annexes I or II as banned substances, but the safety concern is well-documented. Additionally, kavalactones are known CYP450 enzyme inhibitors, potentially causing drug interactions. This risk profile makes them controversial for cosmetic use.

Skin Benefits

  • Traditional topical use for skin conditions
  • Potential anti-inflammatory properties

Known Concerns

  • Documented hepatotoxicity (liver injury cases)
  • CYP450 enzyme inhibition causing drug interactions
  • Neurological effects (kava pyrones)
  • EU food supplement ban reflects regulatory concern

Safety Score

28

Avoid

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

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EU CosIng Database

European Commission cosmetic ingredient registry

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This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.